Park Nicollet International Diabetes Center seeks volunteers with type 2 diabetes for research study
Park Nicollet International Diabetes Center in St. Louis Park is looking for volunteers for a research study to compare the long-term benefits and risks of four widely used diabetes drugs in combination with metformin, the most common first-line medication for treating type 2 diabetes. The National Institutes of Health sponsored project is called the Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness (GRADE) Study and aims to enroll 5,000 participants at 37 research sites nationwide.
If metformin is not enough to help manage type 2 diabetes, a person’s doctor may add one of several other drugs to lower glucose (blood sugar). But while short-term studies have shown the effectiveness of different drugs when used with metformin, there have been no long-term studies of which combination works best and has fewer side effects.
“While metformin is the standard first-line medication for diabetes, it has not been as clear which second-line medication is most effective with metformin,” said John Misa, M.D., chief of primary care, Park Nicollet Clinic, and co-investigator at the Park Nicollet site. “Through this large, long-term study, we will learn which medications work best with metformin, improving our care for all patients with type 2 diabetes.”
The GRADE study will compare drug effects on glucose levels, adverse effects, diabetes complications and quality of life over an average of nearly five years.
Participants will have their diabetes medications managed free of charge through the study, including at least four medical visits per year, but will receive other health care through their own doctors. Participants must have been diagnosed with type 2 diabetes within the last five years and be taking only metformin to treat their diabetes.
To learn more about the GRADE Study, visit https://grade.bsc.gwu.edu/web/grade. To find out if you qualify, contact Penny Thomsen at 952-993-5823 or IDCresearch@parknicollet.com.