Research studies

Principal investigators
David Graft, MD
Brenda Guyer, MD
Pamela Harris, MD
Richard Sveum, MD
Supriya Varadarajulu, MD
Richard Wyatt, MD

Principal investigators
Bruce Burnett, MD
Thomas Davis, MD
Rufino Festin, MD
John Heit, MD, Mayo Clinic, Division of Cardiovascular Disease
Jay Simonson, MD
Sarah Vernon, MD

Investigator-initiated research

Familial Segregation of Venous Thromboembolism
Principal Investigator: John Heit, MD
Sponsor: Doris Duke Charitable Foundation

Principal investigator
Katherine Kendall, MD

Investigator-initiated research

High-Speed Laryngeal Imaging: Normal Physiology
Principal Investigator: Katherine Kendall, MD
Sponsor: Park Nicollet Institute

Principal investigators
Diann Ackard, PhD, LP
Jillian Croll, PhD, RD, MPH, The Emily Program
Scott Crow, MD
Elke Eckert, MD, University of Minnesota
Annie Heiderscheit
Joel Jahraus, MD
Helene Keery, PhD, LP, The Emily Program
Monica Luciana, PhD, University of Minnesota
Betty Schmidt, RN
Robyn Swenson, PhD, LP

Investigator-initiated research

Anna Westin House Residential Outcomes Study
Principal Investigator: Jillian Croll, PhD, RD, MPH
Sponsor: Blue Cross Blue Shield of Minnesota Foundation

Brain Changes in Anorexia Nervosa
Principal Investigator: Elke Eckert, MD
Sponsors: University of Minnesota and Eating Disorders Institute

Can a Milieu-Based Binge Eating Disorder Program Reduce Overweight and Obesity?
Principal Investigator: Diann Ackard, PhD, LP
Sponsor: Obesity Consortium of Minnesota

A Comparison of the Impact of Appearance-Related Teasing on Adolescents Seeking Treatment for an Eating Disorder and a Community Sample of Adolescents
Principal Investigator: Helene Keery, PhD
Sponsor: Park Nicollet Foundation

The Cost of Bulimia Nervosa
Principal Investigator: Scott Crow, MD
Sponsors: University of Minnesota and Eating Disorders Institute

The Effectiveness of Music Listening for Managing Stress and Anxiety for Eating Disorder Patients during Mealtimes
Principal Investigators: Jillian Croll, PhD, RD, MPH, and Annie Heiderscheit
Sponsor: Park Nicollet Foundation

Evaluating the Effectiveness of Partial and Inpatient Hospitalization Programs at the Eating Disorders Institute: One to Ten-Year Outcomes
Principal Investigator: Diann Ackard, PhD, LP
Sponsor: Park Nicollet Foundation

Evaluation of a Milieu-Based Medical Weight Management Program
Principal Investigator: Joel Jahraus, MD
Sponsor: Obesity Consortium of Minnesota

Pattern Recognition Process with Women in Recovery from an Eating Disorder
Principal Investigator: Betty Schmidt, RN
Sponsor: Park Nicollet Foundation

Stage of Change as a Predictor of Treatment Outcome among Individuals Seeking Treatment for an Eating Disorder
Principal Investigators: Diann Ackard, PhD, LP, and Jillian Croll, PhD, RD, MPH
Sponsor: Park Nicollet Foundation

A Ten-Year Follow-Up Study Examining Cross-Cultural Differences between High-School Aged African American, Caucasian American, Bahamian and Namibian Males and Females with Regard to Body Dissatisfaction and Other Eating Disorder Risks
Principal Investigator: Robyn Swenson, PhD, LP
Sponsors: Park Nicollet Institute and Park Nicollet Foundation

The Treatment of Binge Eating Disorder Using Psychoeducational and Cognitive-Behavioral Techniques: A Pilot Study
Principal Investigator: Diann Ackard, PhD, LP
Sponsor: Park Nicollet Foundation

Principal investigators
Donald Pine, MD
Ingrid Yelkin, MD

Investigator-initiated research

Development of a Clinician Referral Intervention to Tobacco Quitlines
Principal Investigator: Donald Pine, MD
Sponsor: Park Nicollet Foundation

A Qualitative Comparison of Community Resources for Pregnant Adolescents in St. Louis Park, Minnesota and Westport, New Zealand
Principal Investigator: Ingrid Yelkin, MD
Sponsor:  Park Nicollet Foundation

Principal investigators
Aaron Folsom, MD, University of Minnesota
Russell Luepker, MD, University of Minnesota

Federally or nationally funded multicenter studies

Atherosclerosis Risk in Communities (ARIC) Study
Principal Investigator: Aaron Folsom, MD
Sponsor: National Heart, Lung, and Blood Institute

Community Surveillance of Congestive Heart Failure
Principal Investigator: Russell Luepker, MD
Sponsor: National Institutes of Health

Principal investigators
Renner Anderson, MD
Mary Sue Beran, MD, MPH
Barbara Braun, PhD
Michael Callahan, HealthFront
Jinnet Fowles, PhD
Allan Kind, MD
Sharon Rolnick, PhD, HealthPartners Research Foundation
Paul Terry, PhD
Feifei Wei, PhD, HealthPartners Research Foundation

Investigator-initiated research

The Effects of Stand Alone Diabetes Management Coaching Service versus a Coaching Service Integrated with Primary Care Practice
Principal Investigator: Paul Terry, PhD
Sponsor: GlaxoSmithKline

E-Indicators of Health Care Provider Performance:  Developing, Evaluating and Implementing Electronic Health Record-based Quality Indicators for Ambulatory and Integrated Health Care Systems
Principal Investigator: Jinnet Fowles, PhD
Sponsors: The Commonwealth Fund and Robert Wood Johnson Foundation

How Do High-Deductible Health Plans and Pay-for-Performance Incentives Impact the Patient-Physician Relationship?
Principal Investigator: Mary Sue Beran, MD, MPH
Sponsor: Park Nicollet Institute

Patient On-Line Evaluation – Cardiology
Principal Investigator: Allan Kind, MD
Sponsor: Park Nicollet Health Services

Patient On-Line Evaluation – Rheumatology
Principal Investigator: Allan Kind, MD
Sponsor: Curtis L. Carlson Family Foundation

Physician Practice Response to Incentive Programs
Principal Investigator: Michael Callahan
Sponsor: Agency for Healthcare Research and Quality

Weight Management, Physical Activity, Less Disability in Rheumatoid and Osteoarthritis
Principal Investigator: Barbara Braun, PhD
Sponsor: Centers for Disease Control and Prevention

Federally or nationally funded multicenter studies

Cancer Surveillance in HMO Administrative Data
Principal Investigator: Feifei Wei, PhD
Sponsor: National Institutes of Health

Colon Cancer Survivors: Medication and Risk of Recurrence
Principal Investigator: Sharon Rolnick, PhD
Sponsor: National Institutes of Health

Safety Data Link Project
Principal Investigator: Renner Anderson, MD
Sponsor: Centers for Disease Control and Prevention

Principal investigators
Kris Haugen
Mary Kruse
Paul Terry, PhD

Investigator-initiated research

Improving Physical Activity and Preventing Relapse in a Health Care Employee Population
Principal Investigator: Mary Kruse
Sponsor: Park Nicollet Foundation

Park Nicollet Healthy Living Program: A Health Promotion Program for Park Nicollet Employees
Principal Investigator: Kris Haugen
Sponsor: Park Nicollet Health Services

Standard Worksite Health Program versus Activated Consumer
Principal Investigators: Paul Terry, PhD
Sponsor: Centers for Disease Control and Prevention

Principal investigators
Harold Martin, MD
Nila Suntharam, MD

Federally or nationally funded multicenter studies

A Study to Understand the Natural History of HIV and AIDS in the Era of Effective Therapy
Principal Investigator: Harold Martin, MD
Sponsor: National Institutes of Health

Treatment IND: Use of Sodium Stibogluconate (PentostamR) to Treat Mucocutaneous Leishmaniasis
Principal Investigators: Harold Martin, MD, and Nila Suntharam, MD
Sponsor: Centers for Disease Control and Prevention

Principal investigator
Anthony Woolley, MD

Principal investigators
Richard Bergenstal, MD
Amy Criego, MD
Robert Cuddihy, MD
Rowan DeBold, MD
Roger Mazze, PhD
Margaret Powers, PhD
William Richards, MD

Investigator-initiated research

Assessment of Non-Fasting versus Fasting Lipid Measures in Diabetes Patients
Principal Investigator: William Richards, MD
Sponsor: MedPoint Pharmaceuticals

Evaluation of Glucose Monitoring Methods:  Characterizing Glycemic Control in Subjects with Diabetes
Principal Investigator: Roger Mazze, PhD
Sponsor: Lifescan

Impact of a Continuing Medical Education Program for Primary Care Providers on Self-Reported Confidence and Use of Insulin in Persons with Type 2 Diabetes
Principal Investigator: Margaret Powers, PhD

Impact of Self Monitoring Blood Glucose Frequency on Glycemic Control in Patients with Type 2 Diabetes
Principal Investigator: Richard Bergenstal, MD
Sponsor: Lifescan

Observational Study of Interstitial Glucose Monitoring with Continuous Glucose Monitoring to Track Patients Treated with Exenatide
Principal Investigator: Roger Mazze, PhD
Sponsor: Eli Lilly

Federally or nationally funded multicenter studies

Action to Control Cardiovascular Risk in Diabetes (ACCORD)
and Action to Control Cardiovascular Risk in Diabetes:
 - Ancillary Eye Study
 - Memory in Diabetes Substudy
 - Intensive Glycemic Control and Skeletal Health Study
Local Principal Investigator: Richard Bergenstal, MD
Sponsor: National Institutes of Health

Epidemiology of Diabetes Intervention and Complications (EDIC)
Principal Investigator: Richard Bergenstal, MD
Sponsor: National Institutes of Health

Natural History of the Study of the Development of Type 1 Diabetes
Principal Investigator: Amy Criego, MD
Sponsor: National Institutes of Health

Principal investigators
Sandra Hanson, MD
Brian Martinson, PhD, HealthPartners Research Foundation
Frederick Taylor, MD
Richard Veyna, MD
Wylie Zhu, MD

Investigator-initiated research

A Single-Center Pharmacoeconomic Study of BOTOX (Botulinum Toxin Type A) for the Prophylactic Treatment of Migraine Headache
Principal Investigator: Frederick Taylor, MD
Sponsor: Allergan

Federally or nationally funded multicenter studies

Albumin in Acute Stroke (ALIAS) Trial:  A Phase III Randomized Multicenter Clinical Trial of High-Dose Human Albumin Therapy for Neuroprotection in Acute Ischemic Stroke
Principal Investigator: Sandra Hanson, MD
Sponsor: National Institute of Neurological Disorders and Stroke

Carotid Occlusion Surgery Study (COSS)
Principal Investigator: Sandra Hanson, MD
Sponsor: National Institutes of Health

A Phase III, Randomized, Multicenter, Open-Label, 900-Subject Clinical Trial That Will Explain Whether a Combined Intravenous (IV) and Intra-arterial (IA) Approach to Recanalization is Superior to Standard IV rt-PA (Activase) Alone When Initiated Within Three Hours of Acute Ischemic Stroke Onset
Principal Investigator: Sandra Hanson, MD
Sponsor: National Institutes of Health

Population-Based Stroke Epidemiology and Outcomes: The Minnesota Stroke Survey
Principal Investigator: Brian Martinson, PhD
Sponsor: National Institute of Neurological Disorders and Stroke

Randomized Evaluation of Carotid Occlusion and Neurocognition (RECON)
Principal Investigator: Sandra Hanson, MD
Sponsor: National Institutes of Health

Principal investigator
Kristine Peterson, RN, MS, CCRN

Investigator-initiated research

Incontinence Management and Perineal Skin Care in Acutely and Critically Ill Patients:  Nurses’ Knowledge and Practices
Principal Investigator: Kristine Peterson, RN, MS, CCRN
Sponsor: Park Nicollet Institute

Federally or nationally funded multicenter study

Development of an Evidence-Based Protocol for Prevention of Perineal Dermatitis in Hospitalized Adults with Incontinence
Principal Investigator: Kristine Peterson, RN, MS, CCRN
Sponsor: American Association of Critical Care Nurses

Principal investigators
Michael Valley, MD

Principal investigator
David Parker, MD

Investigator-initiated research

Effectiveness of a Machine Guarding Intervention
Principal Investigator: David Parker, MD
Sponsor: National Institute for Occupational Safety and Health

A Randomized Intervention of Collision Repair Shops
Principal Investigator: David Parker, MD
Sponsor: National Institute for Occupational Safety and Health

Principal investigators
Peter Argenta, MD
Rachel Ghebre, MD
Keith Heaton, MD
Joseph Leach, MD
Mary Jo Nissen, PhD, MPH
Julie Ross, PhD, University of Minnesota Cancer Center
Alice Shapiro, PhD, RD, LN
Karen Swenson, PhD, RN, MS, AOCN
Todd Tuttle, MD

Investigator-initiated research

Continuity of Care for Cancer Survivors
Principal Investigator: Mary Jo Nissen, PhD, MPH
Sponsor: Park Nicollet Foundation

Predictors of Lymphedema following Breast Cancer Surgery
Principal Investigator: Karen Swenson, PhD, RN, MS, AOCN
Sponsor: U.S. Army Medical Research

Federally or nationally funded multicenter studies

A Clinical Trial to Determine the Efficacy of a Dietary Fat Reduction Program in Addition to Systemic Adjuvant Therapy in the Management of Patients with Primary Breast Disease (WINS) and Dietary Intake in Women with Breast Cancer
Principal Investigator: Alice Shapiro, PhD, RD, LN
Sponsor: American Health Foundation

A Phase III Randomized Trial of Paclitaxel and Carboplatin versus Triplet or Sequential Doublet Combinations in Patients with Epithelial Ovarian or Primary Peritoneal Carcinoma
Principal Investigator: Peter Argenta, MD
Sponsor:  National Cancer Institute

A Pilot Study of L-Carnitine Supplementation in the Prevention of Paclitaxel (Taxol)-Induced Peripheral Neuropathy in Women with Breast Cancer
Principal Investigator: Alice Shapiro, PhD, RD, LN
Sponsor: University of Minnesota Cancer Center

Predictors of Adult Leukemia in Minnesota
Principal Investigator: Julie Ross, PhD
Sponsor: National Cancer Institute

A Prognostic Study of Sentinel Node and Bone Marrow Micrometastases in Women with Clinical Stage T1 or T2 Breast Cancer
Principal Investigator: Keith Heaton, MD
Sponsor: American College of Surgeons

A Randomized Trial of Axillary Node Dissection in Women with Clinical T1 – T2 NO MO Breast Cancer Who Have a Positive Sentinel Node
Principal Investigator: Keith Heaton, MD
Sponsor: American College of Surgeons

Sentinel Lymph Node Biopsy before Preoperative Chemotherapy: Factors Associated with Non-Sentinel Lymph Node Metastases
Principal Investigator: Todd Tuttle, MD
Sponsor: University of Minnesota Cancer Center

Principal investigator
Anton Willerscheidt, MD

Investigator-initiated research

INTACTS Prescription Inserts for Keratoconus (0.25mm, 0.30mm and 0.35mm) (HUD)
Principal Investigator: Anton Willerscheidt, MD

Principal investigators
Kirk Aadalen, MD
Deborah Bohn, MD
Joel Boyd, MD
Jeffrey Dick, MD, Orthopaedic Consultants, P.A.
William Ford, MD
Jeffrey Husband, MD
Greg Lervick, MD, Minnesota Sports Medicine
Scott McPherson, MD
John Sherman, MD, Orthopaedic Consultants, P.A.
Marc Swiontkowski, MD

Investigator-initiated research

Accelerated Rehabilitation Protocol for Distal Radius Fractures Treated with Volar Open Reduction and Internal Fixation
Principal Investigator: Jeffrey Husband, MD
Sponsor: DePuy Orthopaedics

The Incorporation Properties of the Regeneration Technologies Inc. Bone Screws for Anterior Cruciate Ligament Reconstruction Using Bone Tendon Bone Auto and Allografts
Principal Investigator: Joel Boyd, MD
Sponsor: Regeneration Technologies

Outcome of All-arthroscopic Rotator Cuff Repair Using Single Row Fixation Technique
Principal Investigator: Greg Lervick, MD

Rate of Functional Recovery after Anterior Cruciate Ligament Reconstruction
Principal Investigator: Marc Swiontkowski, MD
Sponsor: Stryker Endoscopy

Rate of Functional Recovery after Carpal Tunnel Release
Principal Investigator: Deborah Bohn, MD

Principal investigator
Martha Spencer, MD

Principal investigators
Edward Lovaas, MD
Jane Nemecek, MD

Principal investigators
Peter Kent, MD
Eric Schned, MD
John Schousboe, MD
Robert Tierney, MD

Investigator-initiated research

Accuracy of Lateral X-ray Absorptiometry to Detect Vertebral Compression Fracture Deformities Compared to Standard Radiography, and Impact of their Detection on Therapy to Prevent Osteoporotic Fracture
Principal Investigator: John Schousboe, MD
Sponsors: Hologic Inc. and Park Nicollet Institute

Association between Abdominal Aortic Calcification Scored on Lateral Spine Images Obtained with Densitometry and Subsequent Cardiac Disease Incidence and Mortality among Elderly Women
Principal Investigator: John Schousboe, MD
Sponsor: Hologic Inc.

Determinants of Oral Medication Adherence in Osteoporosis: The Role of Medication Beliefs
Principal Investigator: John Schousboe, MD
Sponsor: Proctor & Gamble

Federally or nationally funded multicenter studies

BioMarkers for Anti-TNF Response in Rheumatoid Arthritis
Principal Investigator: Eric Schned, MD
Sponsor: National Institutes for Health

The Genetics of Rheumatoid Arthritis (NARAC II)
Principal Investigator: Robert Tierney, MD
Sponsor: Rheumatoid Arthritis Investigator Network

Principal investigator
William Borkon, MD

Principal investigators
Cordelia Erickson-Davis
Marjorie Johnson
Martha Nance, MD
Sotirios Parashos, MD
Dorothy Vawter, Minnesota Center for Health Care Ethics
Catherine Wielinski

Investigator-initiated research

Challenges in Speech and Communication in Progressive Supranuclear Palsy (PSP)
Principal Investigator: Marjorie Johnson
Sponsor: Dyer Family Foundation

Clinimetric Studies of a New Scale for Parkinson’s Disease
Principal Investigator: Sotirios Parashos, MD
Sponsor: University of Chicago and Struthers Parkinson’s Center

Cognitive Dysfunction in Parkinson’s Disease, with and without Dementia Evaluation using the Cognitive Linguistic Quick Test
Principal Investigator: Sotirios Parashos, MD
Sponsor: Struthers Parkinson’s Center

The Impact of Young Onset Parkinson’s Disease on Employment
Principal Investigators: Sotirios Parashos, MD, and Catherine Wielinski
Sponsor: Struthers Parkinson’s Center

Neurofeedback Training for Dyskinesia in Parkinson’s Disease
Principal Investigator: Cordelia Erickson-Davis
Sponsor: Struthers Parkinson’s Center

Physical Therapy Assessments in Parkinson’s Disease
Principal Investigator: Catherine Wielinski
Sponsor: Struthers Parkinson’s Center

Validation of the Cognitive Performance Test in Parkinson’s Disease
Principal Investigator: Catherine Wielinski
Sponsor: Struthers Parkinson’s Center

Federally or nationally funded multicenter studies

Falls Interview for Parkinson’s Disease
Principal Investigator: Catherine Wielinski
Sponsor: National Parkinson Foundation

Genetic Epidemiology of Parkinson’s Disease
Principal Investigator: Martha Nance, MD
Sponsor: National Institutes of Health

Genetic Linkage Study in Parkinson’s Disease (GenePD)
Principal Investigator: Martha Nance, MD
Sponsor: National Institutes of Health

Revisiting Predictive Testing for the Adult Onset Neurogenetic Disorders
Principal Investigator: Martha Nance, MD
Sponsor: Huntington Study Group

Risk and Protective Factors for Falls in Parkinson’s Disease
Principal Investigator: Catherine Wielinski
Sponsor: National Parkinson Foundation

Principal investigator
William Borkon, MD

Principal investigator
Jeffrey Mendeloff, MD

Federally or nationally funded multicenter study

Artery Wall Hypoxia and Intimal Hyperplasia
Principal Investigator: Jeffrey Mendeloff, MD
Sponsor: National Institutes of Health

Principal investigators
Kirk Allison
Shawn Brown
Leah Burton
Melissa Constantine
Sujata Costello, MD
Maria Frisch
Jennifer Hanson
Angie Lillehei, RN, MPH
Kristin Moy
Rebecca Seifert
David Tapper, MD
Vivek Thumbigere-Math

Bisphosphonate Therapy Associated Osteonecrosis of the Jaw - Retrospective Cohort Study
Principal Investigator: Vivek Thumbigere-Math
Oral Biology, University of Minnesota

Breast Cancer Susceptibility: A Possible Role for Nucleotide Excision Repair
Principal Investigator: Kristin Moy
School of Public Health, University of Minnesota

Childhood Obesity in a Developing Country
Principal Investigator: Sujata Costello, MD
Park Nicollet Family Medicine Resident

Comparison of Visual Acuity in Pediatric Patients with Amblyopia using Allen Figures and Snellen Optotypes of the M&S SmartSystem II
Principal Investigator: Shawn Brown
Orthoptic Fellowship, Park Nicollet Department of Pediatric Ophthalmology

A Discrete Choice Model Analysis of Health Insurance Transition, Branding Effect and Status Quo
Principal Investigator: Kirk Allison
Health Services Research, Policy and Administration, University of Minnesota

The Effect of Institutionalization of Medical Care on Prenatal Care
Principal Investigator: Melissa Constantine
School of Public Health, University of Minnesota

Influence of Food Focus during Family Mealtimes on Eating Disorder Symptomatology
Principal Investigator: Jennifer Hanson
North Central University

Management of Concussion in Bantam Youth Hockey
Principal Investigator: David Tapper, MD
Park Nicollet Family Medicine Resident

Psychological Differences and Rates of Recovery in Adult Onset versus Youth Onset Anorexia
Principal Investigator: Maria Frisch
Health Services Research and Policy, University of Minnesota

Recovering From an Eating Disorder: A Qualitative Analysis of Women’s Experiences
Principal Investigator: Leah Burton
Minnesota School of Professional Psychology at Argosy University, Twin Cities

Triggers and Outcomes of Binge Eating: A Qualitative Study
Principal Investigator: Rebecca Seifert
Minnesota School of Professional Psychology

Wounds: A Recruitment Pilot Study
Principal Investigator: Angie Lillehei, RN, MPH
School of Nursing, University of Minnesota